San Crisogono is a church in Rome (rione Trastevere) dedicated to the martyr Saint Chrysogonus. It was one of the tituli, the first parish churches of Rome, and was probably built in the 4th century under Pope Silvester I (314–335), rebuilt in the 12th century by John of Crema, and again by Giovanni Battista Soria, funded by Scipione Borghese, in the early 17th century.
The area beneath the sacristy was investigated by Fr. L. Manfredini and Fr. C. Piccolini in 1907. They found remains of the first church (see below). After they had made this discovery, the area was excavated and studied.